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SUMMARY:Image Guided Triggered Drug Delivery - Maya Thanou - Reader\, Inst
 itute of Pharmaceutical Science\, King's College\, London.
DTSTART:20191128T110000Z
DTEND:20191128T120000Z
UID:TALK134920@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:Localised drug delivery to tumours may be applied using blood 
 compatible nano sized carriers able to respond to an external stimulus wit
 h a triggered drug release. Conventional thermos-sensitive liposomes (TSLs
 ) or similar delivery systems lack the labels for in vivo tracking or clin
 ical imaging and hence the ability to assess the optimal trigger time post
  administration. We develop labelled thermosensitive liposomal (iTSL) deli
 very system for localised delivery by Focussed Ultrasound (FUS) triggered 
 release. In addition to labelling for MRI\, we introduced a near-infrared 
 fluorescence (NIRF) label which greatly assists real time tracking of the 
 carrier in our murine xenograft cancer model. This in turn allows for opti
 misation of the FUS conditions and timings\, required for triggered-releas
 e and functional delivery of the therapeutic drugs to tumours. We synthesi
 se these as lipid attached conjugates to ensure specific and lasting label
 ling of the carrier liposomes. MRI contrast enhancement ability and NIRF s
 ignals are assessed in vitro and in vivo. Nanoparticle (iTSLs) kinetics in
  murine tumours are assessed with optical imaging and at defined time inte
 rvals post intravenous injection\, FUS was applied to induce a small incre
 ase in temperature to 42-43°C for 3-5 minutes. Imaging reveals both drama
 tic nanoparticles accumulation and drug release immediately after FUS trea
 tment. Significant tumour growth inhibition is observed for the FUS treate
 d tumours compared to those that were treated only with the drug nanoparti
 cles. The applications of such multifunctional nanotheranostics with short
  and repeated FUS applications could have a transformative effect on cance
 r chemotherapy.
LOCATION:Electrical Engineering\, Department of Engineering - EED Seminar 
 Room - 9 JJ Thomson Avenue\, Cambridge\, CB3 0FA
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