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SUMMARY:Measurement of coronary artery stiffness - Dr M P F Sutcliffe\, CU
 ED
DTSTART:20081031T140000Z
DTEND:20081031T150000Z
UID:TALK13662@talks.cam.ac.uk
CONTACT:Ms Helen Gardner
DESCRIPTION:There are two clinical areas where models of arterial stiffnes
 s have a clear role. Firstly blood pressure in the arterial tree is strong
 ly influenced by changes in the diameter of the arteries\, and high blood 
 pressure is strongly linked with increased mortality. Secondly strokes are
  commonly caused by rupture of arteries\, due presumably to excessive stre
 ss in the artery (as well as physiological changes). To understand these p
 henomena we need to understand the roles of active muscular tone and passi
 ve biomechanical response to loading in controlling the artery diameter an
 d stresses. While there is a lot of effort being put separately into the p
 harmacological behaviour and the mechanical behaviour of arteries\, rather
  little research aims to link the two. Moreover the bioengineering focus h
 as largely been on healthy arteries. This talk will describe work done on 
 mechanical and pharmacological measurement of arterial stiffness of health
 y and diseased coronary arteries. The challenges include the small scale o
 f the specimens\, their complex structure\, difficulties with handling and
  data interpretation.
LOCATION:Oatley Seminar Room\, Department of Engineering
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