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SUMMARY:Species specific transcription in mice carrying a human chromosome
  - Duncan Odom (Cancer Research UK\, CRI)
DTSTART:20081007T120000Z
DTEND:20081007T130000Z
UID:TALK13680@talks.cam.ac.uk
CONTACT:Luca Pellegrini
DESCRIPTION:Homologous sets of transcription factors direct conserved\ntis
 sue-specific gene expression\, yet transcription factor binding events\ndi
 verge rapidly between closely related species.  We used hepatocytes from\n
 an aneuploid mouse strain carrying human chromosome 21 to determine on a\n
 chromosomal scale whether interspecies differences in transcriptional\nreg
 ulation are primarily directed by human genetic sequence or mouse nuclear\
 nenvironment.  Virtually all transcription factor binding locations\,\nlan
 dmarks of transcription initiation\, and the resulting gene expression\nob
 served in human hepatocytes were recapitulated across the entire human\nch
 romosome 21 in the mouse hepatocyte nucleus.  Thus\, in homologous tissues
 \,\ngenetic sequence is largely responsible for directing transcriptional\
 nprograms\; interspecies differences in epigenetic machinery\, cellular\ne
 nvironment\, and transcription factors themselves play secondary roles.\n
LOCATION:Lecture Theatre\, Biochemistry\, Department of (Sanger Building)
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