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SUMMARY:Engineering advanced neural interfaces - Christopher Proctor Engin
 eering Department\, University of Cambridge\, Cambridge\, UK
DTSTART:20200212T130000Z
DTEND:20200212T140000Z
UID:TALK137518@talks.cam.ac.uk
CONTACT:75721
DESCRIPTION:Despite tremendous research efforts\, treatment options for ma
 ny neurological disorders are inadequate. Systemic drug treatments suffer 
 from side effects and long-term habituation\; electrical stimulation is un
 specific\; and the fluidic injection of drugs often displaces the very cel
 ls that are being targeted due to the local pressure increase. Thus\, ther
 e exists a pressing need to develop novel treatment strategies that overco
 me these limitations. One such technology is the recently introduced drug 
 delivery platform known as the microfluidic ion pump (µFIP). The µFIP is
  an implantable device that electrophoretically pumps ions (eg. neurotrans
 mitters\, drugs\, etc) to the target tissue. In addition to spatial and te
 mporal control\, a distinctive feature of the µFIP is that it delivers ju
 st the ion and not the solvent and thus does not increase pressure at the 
 outlet. This "dry" delivery is of paramount importance for neural interfac
 ing as it enables an intimate interface between the drug delivery outlet a
 nd the target cells.  Here we report recent advances in precise engineerin
 g to incorporate µFIPs into implantable devices for treating neurological
  disorders including both depth probes and cortical arrays with recording 
 capabilities. The efficacy of the µFIP platform is demonstrated by stoppi
 ng epileptic seizures in vivo. This is the first in vivo demonstration of 
 an ion pump for treating a neurological disorder and offers a glimpse of w
 hat can be achieved by tailored engineering of the µFIP platform. We anti
 cipate this work to be the starting point for new stimulation\, recording 
 and drug delivery paradigms in chronic neural implantation.
LOCATION:Dept Chemical Engineering and Biotechnology\, Philippa Fawcett Dr
 ive CB3 OAS (Lecture Theatre 3\, Level 3 )
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