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SUMMARY:Optical superresolution microscopy of molecular mechanisms of dise
 ase -  Prof Clemens Kaminski\, Department of Chemical Engineering and Biot
 echnology\, Cambridge
DTSTART:20200306T140000Z
DTEND:20200306T150000Z
UID:TALK137521@talks.cam.ac.uk
CONTACT:Hilde Hambro
DESCRIPTION:Key Words: nanoscopy\, live cell imaging\, neurodegeneration\,
  protein self-assembly reactions\n \nThe self-assembly of proteins into or
 dered macromolecular structures is fundamental to a variety of diseases\, 
 for example in neurodegeneration\, where misfolded proteins aggregate into
  toxic fibrillar shapes\, or during virus replication\, where the assembly
  of functional virions in the host cell is a tightly organized process.  \
 nIn this talk\, I will give an overview of optical imaging techniques (1-3
 ) that allow us to gain insights into protein self-assembly reactions in v
 itro (4 - 7)\, in cells (8 - 10)\, and in live model organisms of disease 
 (11). In particular\, we wish to understand how proteins nucleate to form 
 functional or toxic structures and to correlate such information with biol
 ogical phenotypes. I will show how single molecule localization microscopy
 \, and developments in high speed structured illumination microscopy are c
 apable of tracking the aggregation of proteins in vitro and in vivo\, and 
 how such data are interpreted in the context of disease (11-17).\n\nRefere
 nces:\n(1) F. Stroehl and C.F. Kaminski\, Optica (2016)\n(2) M. Fantham an
 d C.F. Kaminski\, Nat. Phot. (2016)\n(3) F. Stroehl et al.\, Sci. Rep. (20
 16)\n(4) G.S. Kaminski Schierle\, et al\, JACS (2011)\n(5) D. Pinotsi et a
 l\, Nano Letters (2013)\n(6) R. Laine et al\, Nat. Comms (2018)\n(7) R. La
 ine et al\, eLife (2018)\n(8) E. Avezov et al.\, Nat. Cell Biol.(2018)\n(9
 ) D. Pinotsi et al\, PNAS (2016)\n(10) M. Lu et al\,  JBC (2019)\n(11) G.S
 . Kaminski Schierle et al\, ChemPhysChem (2011)\n(12) C. Michel\, et al\, 
 JBC (2014)\n(13) T. Murakami\, et al\, Neuron (2015)\n(14) H. Wong\, et al
 \, Neuron (2017) \n(15) G. Fusco\, et al\, Nat. Comms. (2016)\n(16) S. Qam
 ar\, et al\, Cell (2018)\n(17) J. Lautenschlaeger et al.\, Nat. Comms. (20
 18) \n
LOCATION:Oatley Seminar Room\, Department of Engineering
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