BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Arterial redox signalling in the control of bood pressure under in
 flammatory conditions - Professor Roland Stocker | Victor Chang Cardiac Re
 search Institute\, Australia 
DTSTART:20200213T153000Z
DTEND:20200213T163000Z
UID:TALK138583@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Under inflammatory conditions\, the haem-containing indoleamin
 e 2\,3-dioxygenase 1 is expressed in arterial endothelial cells. In the pr
 esence of hydrogen peroxide\, the endothelial enzyme generates 1O2 and tha
 t this is associated with the stereoselective oxidation of L-tryptophan to
  a tricyclic hydroperoxide via a previously unrecognized oxidative activat
 ion of the dioxygenase activity. The tryptophan-derived hydroperoxide acts
  in vivo as a signalling molecule\, inducing arterial relaxation and decre
 asing blood pressure\; this activity is dependent on Cys42 of protein kina
 se G1α. Our findings demonstrate a pathophysiological role for singlet ox
 ygen in mammals through formation of an amino acid-derived hydroperoxide t
 hat regulates vascular tone and blood pressure under inflammatory conditio
 ns.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
END:VEVENT
END:VCALENDAR