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SUMMARY:Dr Fahim will be presenting a seminar on some of the work he has r
 ecently undertaken - Dr Muhammad Fahim Associate Professor Director of the
  Centre for Omic Sciences\, Islamia College University Peshawar\, Pakistan
DTSTART:20200131T130000Z
DTEND:20200131T140000Z
UID:TALK138853@talks.cam.ac.uk
CONTACT:23263
DESCRIPTION:Plants continuously adjust their strategies to optimize the ba
 lance between growth and defense under ever changing environmental conditi
 ons. In Arabidopsis\, global surveillance to remove aberrant transcripts i
 s mainly maintained by nonsense-mediated mRNA decay (NMD)\, in which UP-FR
 AMESHIFT (UPF) 1 and 3 play a vital role. Though it has been known that NM
 D regulates a subgroup of nucleotide-binding (NB)\, leucine-rich repeat (L
 RR) receptors (NLRs) to repress autoimmunity\, little is known about NMD-m
 ediated NLR regulation under different temperatures and its role to repres
 s autoimmunity. Also\, whether NMD regulates downstream components of thes
 e NLRs\, still remains elusive. \n\nHere we showed that when NMD is defect
 ive\, plants shift prioritization toward defense from growth/development a
 t low temperatures. upf1-5 upf3-1 mutants showed a hypersensitive growth a
 rrest response only at a low temperature. Gene ontology terms related to d
 efense were gradually enriched in upf1-5 upf3-1 mutants as temperature dec
 reased\, whereas terms related to growth/development were gradually deplet
 ed. upf1-5 upf3-1 mutants accumulate high levels of salicylic acid that le
 ads to hypersensitivity at 16°C and inhibition of SA biosynthesis rescued
  the hypersensitivity. upf1-5 upf3-1 mutants showed upregulation of genes 
 involved in defense and SA biosynthesis/signaling. Hypersensitivity seen a
 t a low temperature in upf1-5 upf3-1 mutants required light. Four nucleoti
 de-binding\, leucine-rich repeat genes (two Toll-Interleukin-Resistance do
 main-containing proteins\, ADR1-LIKE 2\, and a TIR-NBS-LRR protein) are im
 portant for the hypersensitive response and they were under temperature-de
 pendent NMD regulation. NMD also regulates the downstream components such 
 as EDS1\, SARD1 and WRKY transcription factors. \n\nTaken together\, our d
 ata suggest that both temperature-dependent NMD and light are important fo
 r maintaining the balance between growth/development and defense to optimi
 ze plant fitness.\n
LOCATION:Seminar Room\, Dept of Plant Sciences
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