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SUMMARY:A custom-designed microfluidic model allows production of biologic
 ally-relevant occlusive thrombi in vitro - Jessica Berry (Cambridge)
DTSTART:20200213T130000Z
DTEND:20200213T140000Z
UID:TALK138907@talks.cam.ac.uk
CONTACT:George Fortune
DESCRIPTION:Traditional flow models have provided valuable insight into th
 e mechanisms of arterial thrombosis. However\, these models usually fail t
 o simulate the occlusive thrombi that cause heart attacks and strokes. Thi
 s limits the usefulness of these models in assessing new anti-thrombotic d
 rugs. Murine artery injury models are often used\, but they are limited by
  the inherent differences of human and mouse platelets. Thus\, there is a 
 need for a more biologically relevant in vitro model that uses human blood
  and more accurately replicates the arterial thrombosis seen in the human 
 body.\n\nWe have developed an in vitro microfluidic model\, using whole hu
 man blood\, which reliably produces occlusive thrombi. The custom-designed
  microfluidic chamber has a branched structure and incorporates a line of 
 high concentration EDTA to quench downstream coagulation. The antithrombot
 ic drug eptifibatide has been tested in both EDTA-quenched and unquenched 
 devices\, and the results show a clear need for this addition if meaningfu
 l results are to be gained from these models.\n\nThis assay provides a rob
 ust and biologically relevant method for testing the ability of antithromb
 otics to prevent occlusive clot formation\, and for exploring the mechanis
 ms underlying arterial thrombosis.
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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