BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Navigation on the microscale - how cells can sense the direction o
 f external gradients - Ulrich Dobramysl (Cambridge)
DTSTART:20200227T130000Z
DTEND:20200227T140000Z
UID:TALK138934@talks.cam.ac.uk
CONTACT:George Fortune
DESCRIPTION:In many biological processes\, in particular embryonic and bra
 in development\, cells need to follow chemical gradients to arrive at a pr
 ecise location. To this end\, they need to be able to determine the direct
 ion and position of sources releasing diffusing molecular guidance cues fr
 om information gathered by receptor clusters located on the cell membrane.
  I will talk about what we learned regarding the limits of direction sensi
 ng in different environments from developing an analytical model\, using a
 n asymptotic approach in two and three dimensions\, and an efficient numer
 ical simulation procedure to calculate the particle fluxes to receptors. I
  will discuss how we quantify the uncertainty associated with location tri
 angulation and that the number of receptors decreases the uncertainty supe
 r-exponentially\, enabling position reconstruction over large distances. F
 inally\, I will show simulations of cells navigating in chemicals gradient
  based on these findings.
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
END:VEVENT
END:VCALENDAR