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SUMMARY:The enigma of histone 3 lysine 4 methylation - Prof. Francis Stewa
 rt\; Professor of Genomics &amp\; Director of the Biotechnology Center\, T
 he Technical University of Dresden\, Germany 
DTSTART:20200212T120000Z
DTEND:20200212T130000Z
UID:TALK139108@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:All active eukaryotic promoters are characterised by nucleosom
 es that are trimethylated on histone 3 lysine 4 (H3K4me3) and most mammali
 an enhancers display H3K4me1. Consequently current dogma contends that H3K
 4 methyltransferases operate as co-factors in transcriptional activation. 
 Functional scrutiny does not sustain this dogma. In yeast\, which has only
  one H3K4 methyltransferase - Set1C\, originally described by my lab and a
 lso called COMPASS\, loss of Set1C counterintuitively promotes more increa
 sed gene expression than reduced. In mammals\, the six H3K4 methyltransfer
 ases have very specific\, not general\, functions in mouse development. 
LOCATION:Babraham - The Cambridge Building - The Petersfield Lecture Theat
 re
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