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SUMMARY:Circular RNAs and their molecular roles in myogenesis and in rhabd
 omyosarcoma - Francesca Rossi\; Sapienza University
DTSTART:20200514T110000Z
DTEND:20200514T120000Z
UID:TALK139135@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Circular RNAs are covalently closed RNA molecules\, ubiquitous
 ly expressed among eukaryotes. Their conservation among different species\
 , spatio-temporal regulation and abundance suggest important biological ro
 les. We previously identified several circular RNAs modulated during human
  myogenesis. Among them\, circ-ZNF609 has a role in regulating primary myo
 blasts proliferation. To better investigate circ-ZNF609’s functions\, we
  studied it in rhabdomyosarcoma\, a paediatric skeletal muscle malignancy.
  We found that circ-ZNF609 is up-regulated in cell lines and in tissue bio
 psies of the tumour\, and that its knock-down strongly delays the G1-S tra
 nsition. Thanks to bioinformatics analyses performed on RNA-seq data from 
 circ-ZNF609-depleted RMS cells and to the study of its molecular partners\
 , we elucidated some of the affected pathways. Since we are interested in 
 discovering other new players in RMS onset and progression\, we selected a
  subset of circular RNAs differentially expressed among human primary myob
 lasts and RMS cells. Thanks to a phenotypic screening\, we aim at characte
 rizing their roles in this disease.
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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