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SUMMARY:Dynamic supramolecular materials for medicine - Prof Dr Tanja Weil
DTSTART:20200205T103000Z
DTEND:20200205T113000Z
UID:TALK139420@talks.cam.ac.uk
CONTACT:Florian Buhr
DESCRIPTION:The extracellular matrix (EM) forms a complex\, supportive env
 ironment for cells providing mechanical and biochemical cues\, and enablin
 g cells to communicate.(1) Evolution has created these unique heterogeneou
 s matrices with inner structure and various functional entities that contr
 ol e.g. pathogen binding and stimulate cell growth and division. We focus 
 on the synthesis of peptide-polymer biomaterials that can serve as synthet
 ic EM-mimicking environments by forming 3D fibril networks (2) or soft pol
 ymers with inner fibril structure (3). Rational optimization of monomer se
 quences and fibril morphologies facilitated dynamic supramolecular network
 s supporting neuronal cells growth in vitro and vivo (4) as well as pathog
 en binding (5). Responsiveness towards various stimuli such as pH changes\
 , light and reactive oxygen species was implemented into the biopolymer se
 quences. In this way\, materials properties were optimized towards enhance
 d bioactivity and customized for their respective microenvironments for e.
 g. local drug delivery (5)\, which offers new avenues for cell and tissue 
 engineering. \n\n(1) R. O. Hynes\, Science (2009)\, 326\, 1216\n(2) S. Sie
 ste\, T. Mack\, C. V. Synatschke\, C. Schilling\, C. Meyer zu Reckendorf\,
  L. Pendi\, S. Harvey\, F. S. Ruggeri\, T. Knowles\, C. Meier\, D.Y.W. Ng\
 , T. Weil\, B. Knöll. (2018) Water-Dispersible Polydopamine-Coated Nanofi
 bers for Stimulation of Neuronal Growth and Adhesion. Adv. Healthc. Mater.
  7\, 11\, 1701485. \n(3) J. Gacanin\, J. Hedrich\, S. Sieste\, G. Glaßer\
 , I. Lieberwirth\, C. Schilling\, S. Fischer\, H. Barth\, B. Knöll\, C. V
 . Synatschke\, T. Weil. (2019) Autonomous Ultrafast Self‐Healing Hydroge
 ls by pH‐Responsive Functional Nanofiber Gelators as Cell Matrices. Adv.
  Mater. 31\, 2\, 1805044.\n(4) C. Schilling\, T. Mack\, S. Sieste\, C. Syn
 atschke\, T. Weil\, B. Knöll. (2018). Sequence-optimized Peptide Nanofibr
 es as Potent Enhancers of Peripheral Neuron Adhesion\, Growth and Regenera
 tion\, accepted.\n(5) M. Yolamanova\, C. Meier\, A.K. Shaytan\, V. Vas\, C
 .W. Bertoncini\, F. Arnold\, O. Zirafi\, S.M. Usmani\, J.A. Müller\, D. S
 auter\, C. Goffinet\, D. Palesch\, P. Walther\, N.R. Roan\, H. Geiger\, O.
  Lunov\, T. Simmet\, J. Bohne\, H. Schrezenmeier\, K. Schwarz\, L. Ständk
 er\, W.-G. Forssmann\, X. Salvatella\, P.G. Khalatur\, A.R. Khokhlov\, T.P
 .J. Knowles\, T. Weil\, F. Kirchhoff\, J. Münch. (2013) Peptide nanofibri
 ls boost retroviral gene transfer and provide a rapid means for concentrat
 ing viruses. Nature Nanotechnol. 8\, 2\, 130-136.\n(6) S. Sieste\, T. Mack
 \, C. V. Synatschke\, C. Schilling\, C. Meyer zu Reckendorf\, L. Pendi\, S
 . Harvey\, F. S. Ruggeri\, T. Knowles\, C. Meier\, D.Y.W. Ng\, T. Weil\, B
 . Knöll. (2018) Water-Dispersible Polydopamine-Coated Nanofibers for Stim
 ulation of Neuronal Growth and Adhesion. Adv. Healthc. Mater. 7\, 11\, 170
 1485.\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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