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SUMMARY:Evolution of Antibiotic Resistance: from the Lab to the Clinic and
  back - Prof. Nathalie Q. Balaban\, The Hebrew University of Jerusalem
DTSTART:20200212T103000Z
DTEND:20200212T113000Z
UID:TALK139573@talks.cam.ac.uk
CONTACT:Magdalena
DESCRIPTION:The evolution of antibiotic resistance in microorganisms is a 
 major health issue. Understanding the evolutionary trajectories from susce
 ptibility to resistance and the factors that affect it is crucial. Quantit
 ative experiments and mathematical modelling can shed light on the process
 es that speed up or delay the evolution of resistance. We previously showe
 d that tolerance\, a form of survival under antibiotics that is distinct f
 rom resistance\, plays a major role in promoting the evolution of resistan
 ce in vitro. In order to determine the relevance of the in vitro experimen
 tal evolution results for the clinic\, we followed the course of infection
  in patients with life threatening bloodstream infections. A striking simi
 larity between the in vitro and in host evolution is observed\, despite th
 e use in patients of combination therapy which was supposed to prevent res
 istance. Further dissection of the response of the clinical strains to com
 bination of antibiotics reveals a new way by which resistance evolution is
  strongly promoted by the tolerance phenotype.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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