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SUMMARY:Adult hippocampal neurogenesis in health and disease  - Dr Pascal 
 Bielefeld\; Swammerdam Institute for Life Sciences\, University of Amsterd
 am\, Netherlands
DTSTART:20200224T120000Z
DTEND:20200224T130000Z
UID:TALK139969@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The extraordinary capacity of the rodent hippocampus to genera
 te new neurons throughout life\, a process known as adult hippocampal neur
 ogenesis\, has been a longstanding research topic. Over the years it has b
 ecome clear that this strictly regulated process is crucial for several hi
 ppocampus-dependent phenomena\, mostly related to memory formation and con
 solidation. Furthermore\, deregulation of the hippocampal neurogenic casca
 de is a widely observed phenomenon in numerous pathologies. This reactive 
 neurogenesis was thought to be a protective\, regenerative intrinsic respo
 nse from the brain\, but over the years it has become clear that pathologi
 cal stimuli can drive aberrant neurogenesis with detrimental consequences 
 for the hippocampal stem cell niche and hippocampal functioning. Over the 
 last 10 years our lab has been studying how adult hippocampal neurogenesis
  is regulated in both physiological and pathological conditions. In this t
 alk I will discuss several highlights from the past years\, spanning gluco
 corticoid-mediated preservation of neural stem cells during ageing to rest
 oring seizure-induced aberrant neurogenesis using microRNAs\, and our rece
 nt attempts to map Traumatic Brain Injury-induced alterations in the hippo
 campal stem cell niche using single cell RNA sequencing. 
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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