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SUMMARY:The Challenges of Meta-analysing Metabolomics Data\; Experiences f
 rom the Consortium Of METabolomics Studies (COMETS). - Dr Rachel Kelly\, C
 hanning Division of Network Medicine\, Brigham and Women’s Hospital &amp
 \; Harvard Medical School\, USA.
DTSTART:20200423T100000Z
DTEND:20200423T110000Z
UID:TALK139972@talks.cam.ac.uk
CONTACT:Paul Browne
DESCRIPTION:This seminar will be broadcast live online\, please register i
 n advance for this meeting:\n\nhttps://mrc-epid.zoom.us/meeting/register/v
 5EtceuhqjguMZey9WROpKEW67x29InsYw\n\nAfter registering\, you will receive 
 a confirmation email containing information about joining the meeting (inc
 luding iCal) from Zoom.\n\nPlease use your institutional email address for
  registration (if possible) and complete your registration at least 30 min
 utes prior to the seminar so that you will receive the confirmation email/
 access link before the seminar. Your registration will be manually checked
  and approved.\n\nGenetics teaches us that for highly-dimensional omic tec
 hnologies sample size is key\, and that necessary sample sizes can best be
  archived via meta-analyses. This poses a challenge for metabolomics due t
 o its relative nature of measurement\, the lack of a standardized metaboli
 te nomenclature and differences in metabolome coverage between platforms. 
 The Consortium Of METabolomics Studies (COMETS)\; has developed a novel wo
 rkflow to deal with these issues for the first time. I will discuss our ex
 periences with COMETS and how we have leveraged these developments to cond
 uct largest and most comprehensive metabolomics of BMI study to date\, inc
 luding >100\,000 adults from 43 cohorts worldwide.
LOCATION:Online
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