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SUMMARY:Innovation in synthetic methodology through use of flow - Prof. Ti
 mothy Noël (Eindhoven University of Technology\, The Netherlands)
DTSTART:20200302T150000Z
DTEND:20200302T170000Z
UID:TALK140083@talks.cam.ac.uk
CONTACT:Lingtao Kong
DESCRIPTION:Until recently\, many reactions have been exclusively performe
 d in conventional batch LabWare. With the advent of microreactor technolog
 y\, significant effort has been devoted to develop a wide variety of conti
 nuous-flow techniques to facilitate organic synthesis. Microreactor techno
 logy offers several advantages compared to traditional batch reactors\, su
 ch as\, enhanced heat- and mass-transfer\, improved irradiation\, safety o
 f operation and the possibility to integrate several reaction steps and su
 bsequent separations in a single streamlined process.1\nMy group has taken
  a great interest in assisting chemists by developing automated and flow-b
 ased reaction technologies capable of reducing manual labor\, increasing t
 he reproducibility of the results and accelerating reaction discovery. Thi
 s further allows the chemists to unravel uncharted chemical space. \nIn th
 is presentation\, we will give an overview of our synthetic methodology de
 velopment\, exemplified by photoredox catalysis2\, C–H activation chemis
 try3 and electrochemistry4 and how these synthetic methods were impacted b
 y continuous-flow microreactor technology. Furthermore\, we will discuss t
 he developed technology and reaction models in detail.\n\nReferences:\n\n1
 . (a) T. Noel\, Y. Cao\, G. Laudadio\, Acc. Chem. Res. 2019\, DOI: 10.1021
 /acs.accounts.9b00412. (b) H. P. L. Gemoets\, Y. Su\, M. Shang\, V. Hessel
 \, R. Luque\, T. Noel\, Chem. Soc. Rev. 2016\, 45\, 83-117. (c) D. Cambie\
 , C. Bottecchia\, N. J. W. Straathof\, V. Hessel\, T. Noel\, Chem. Rev. 20
 16\, 116\, 10276-10341. \n2. (a) D. Cambie\, J. Dobbelaar\, P. Riente Paiv
 a\, J. Vanderspikken\, C. Shen\, P. Seeberger\, K. Gilmore\, M. Debije\, T
 . Noel\, Angew. Chem. Int. Ed. 2019\, 58\, 14374-14378. (b) X.-J. Wei\, I.
  Abdiaj\, C. Sambiagio\, C. Li\, E. Zysman-Colman\, J. Alcazar\, T. Noel\,
  Angew. Chem. Int. Ed. 2019\, 58\,  13030-13034. (c) X.-J. Wei\, W. Boon\,
  V. Hessel\, T. Noel\, ACS Catal. 2017\, 7\, 7136-7140. (b) C. Bottecchia\
 , M. Rubens\, S. Gunnoo\, V. Hessel\, A. Madder\, T. Noel\, Angew. Chem. I
 nt. Ed. 2017\, 56\, 12701-12707. (c) D. Cambie\, F. Zhao\, V. Hessel\, M. 
 G. Debije\, T. Noel\, Angew. Chem. Int. Ed. 2017\, 56\, 1050-1054. (d) N. 
 J. W. Straathof\, S. E. Cramer\, V. Hessel\, T. Noel\, Angew. Chem. Int. E
 d. 2016\, 55\, 15549-15553.\n3. (a) G. Laudadio\, S. Govaerts\, Y. Wang\, 
 D. Ravelli\, H. F. Koolman\, M. Fagnoni\, S. W. Djuric\, T. Noel\, Angew. 
 Chem. Int. Ed. 2018\, 57\, 4078-4082. (b) H. P. L. Gemoets\, G. Laudadio\,
  K. Verstraete\, V. Hessel\, T. Noel\, Angew. Chem. Int. Ed. 2017\, 56\, 7
 161-7165. (c) U. K. Sharma\, H. P. L. Gemoets\, F. Schoeder\, T. Noel\, E 
 Van der Eycken\, ACS Catal. 2017\, 7\, 3818-3823.\n4. (a) G. Laudadio\, A.
  de A. Bartolomeu\, L. M. H. M. Verwijlen\, Y. Cao\, K. T. de Oliveira\, T
 . Noel\, J. Am. Chem. Soc. 2019\, 141\, 11832-11836. (b) G. Laudadio\, E. 
 Barmpoutsis\, C. Schotten\, L. Struik\, S. Govaerts\, D. L. Browne\, T. No
 el\, J. Am. Chem. Soc. 2019\, 141\, 5664-5668.  (b) G. Laudadio\, W. De Sm
 et\, L. Struik\, Y. Cao\, T. Noel\, J. Flow Chem. 2018\, 8\, 157-165. (c) 
 G. Laudadio\, N. J. W. Straathof\, M. D. Lanting\, B. Knoops\, V. Hessel\,
  T. Noel\, Green Chem. 2017\, 19\, 4061-4066.\n
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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