BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Tension heterogeneity instructs morphogenesis and fate specificati
 on during heart development - Dr. Rashmi Priya (Max Planck Institute for H
 eart and Lung Research\, Bad Nauheim\, Germany)
DTSTART:20200313T150000Z
DTEND:20200313T160000Z
UID:TALK140278@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:How ordered complexity (form and fate) emerges in vivo during 
 organogenesis is ill understood. A critical step during vertebrate heart d
 evelopment is trabeculation\, during which the myocardial wall transforms 
 from a monolayer to a complex topological structure consisting of two dist
 inct cell types: outer compact layer (CL) and inner trabecular layer (TL) 
 cardiomyocytes (CMs). Cardiac trabeculation is crucial for heart function.
  Yet\, the mechanisms underlying the emergence and specification of trabec
 ular CMs remain unknown. Using the zebrafish heart in combination with in 
 vivo quantitative imaging\, measurements of tension and genetic mosaic too
 ls\, we now report that tension heterogeneity drives morphogenesis as well
  as cell fate decisions during heart morphogenesis. Proliferation induced 
 crowding generates tension heterogeneity among CL CMs thus driving their d
 elamination from the outer to the inner layer. Inducing contractility augm
 ents CM delamination and strikingly rescues delamination even in absence o
 f critical trabeculation signals. Notably\, mechanical segregation of CMs 
 into compact versus trabecular layer is necessary and sufficient to trigge
 r differential CM fate by inducing differential Notch activity. Broadly\, 
 these findings argue for a system-level approach integrating mechanics wit
 h regulatory circuits for a cogent understanding of organ development.
LOCATION:Hodgkin-Huxley Seminar Room\,  Physiology Building\, Downing Site
  
END:VEVENT
END:VCALENDAR