BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:“Focus on the Individual\; The importance of chromosome-specific
  biology in generating aneuploidy patterns in cancer” - Dr Sarah McClell
 and from Barts Cancer Institute\, Queen Mary University of London 
DTSTART:20200601T120000Z
DTEND:20200601T131500Z
UID:TALK142552@talks.cam.ac.uk
CONTACT:Anna Toporska
DESCRIPTION:The genomes of cancer cells are highly abnormal\, displaying a
 berrations at multiple scales ranging from single bases to copy number alt
 erations (CNAs) affecting whole chromosomes (aneuploidy). Cancer genomes c
 ontinually evolve over each of these scales\, powered both by evolutionary
  selection and high rates of genetic instability including chromosomal ins
 tability (CIN). This ‘slippery characteristic’ of cancer cells likely 
 allows tumours to develop resistance to therapy\, therefore understanding 
 the mechanisms that contribute to chromosomal instability is of key import
 ance. A long-standing enigma of cancer genomes is the presence of recurren
 t patterns of aneuploidy. Since we know little about the selective pressur
 es OR mutation rates of chromosomes\, teasing apart the aetiology and impo
 rtance of these recurrent patterns has not been possible to date. McClella
 nd lab focusses on understanding the processes that generate aneuploidy in
  cancer (Burrell and McClelland et al\, Nature 20131\; Tamura et al\, BioR
 Xiv 20192) and they recently discovered that individual chromosomes behave
  differently during cell division and can thus  become aneuploid or develo
 p CNAs at different rates (Worrall et al\, 20173\; Tovini and McClelland\,
  20194\; Shaikh et al\, BioRXiv 20195). Moreover the specific mechanism ge
 nerating aneuploidy\, for example defects in mitosis\, or aberrant DNA rep
 lication\, generates a specific aneuploidy landscape3\,5. Dr McClelland wi
 ll present the findings they have made from modelling multiple different C
 IN mechanisms in diploid cells\, and also from examining mechanisms and no
 n-random aneuploidy in cancer cell models. She will also discuss the impli
 cations and applications of these findings to interpreting the origins and
  vulnerabilities of chromosomal instability in cancer.\n\n
LOCATION:ZOOM (live)
END:VEVENT
END:VCALENDAR