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SUMMARY:Capillary waves as a label-free detection tool of biomolecules: Pe
 rspective for a droplet-based lab on a chip - Cyril Picard\, Department of
  Applied Mathematics &amp\; Theoretical Physics
DTSTART:20081030T113000Z
DTEND:20081030T123000Z
UID:TALK14271@talks.cam.ac.uk
CONTACT:Dr C. P.  Caulfield
DESCRIPTION:Whatever the context (biotechnology\, molecular biology)\, bio
 chips are now considered as relevant systems to detect biological molecule
 s. Recently\, the idea target molecules can be captured at a functionalize
 d fluid interface has been put forward to develop a new type of biochip ca
 lled fluid biochip with novel perspectives.\nIn particular\, an inexpensiv
 e label free detection is possible thanks to a mechanical transduction bas
 ed on the change of the rheological interfacial properties during the hybr
 idization between probe and target molecules at the fluid interface. The r
 elevance of such a device in the field of DNA detection is studied\nexperi
 mentally. A meniscus capillary wave net is promoted at the surface of a wa
 ter sub-phase contained in cylindrical cell submitted to a vertical\nvibra
 tion. The geometry of the wave net\, which is characterized by two optical
  techniques\, demonstrates a sensitivity to the surface tension and\nto th
 e rheological interfacial properties. This sensitivity is used to detect t
 he presence and the nature of DNA strands (single or double\nstranded) cap
 tured at the interface. The first steps towards the miniaturisation of suc
 h a detection method will be presented as well.\n\n
LOCATION:Open Plan Area\, BP Institute\, Madingley Rise CB3 0EZ
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