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SUMMARY:Biomolecules in accelerated fracture healing - Dr Simon Donell\, C
 onsultant Orthopaedic Surgeon at the Norfolk &amp\; Norwich University Hos
 pital
DTSTART:20081013T110000Z
DTEND:20081013T113000Z
UID:TALK14549@talks.cam.ac.uk
CONTACT:Meera Arumugam
DESCRIPTION:Injuries\, including fractures make up half the work-load of a
 n orthopaedic surgeon. Fractures produce a huge burden on the individual a
 nd on society. Currently many fractures are treated with metal implants to
  hold them. What orthopaedic surgeons would really like is a bone glue tha
 t can be injected and set the fracture without supplementary fixation. The
  use of relevant biomolecules that are involved in the healing process is 
 a step towards that goal. However the biomolecules cannot be used clinical
 ly in isolation from scaffolds\, and there may be a significant role for i
 ncluding cells in any material that can accelerate fracture healing.\nThis
  presentation will outline how a fracture is treated\, how it heals\, and 
 the potential technologies available to assist the healing process\, an ov
 erview of the basic science and then review the current possible biomolecu
 les.\nThe current biomolecules available clinically are bone morphogenetic
  proteins -2 and -7\, and parathyroid hormone. The presentation will cover
  the clinical trials that have and are being conducted with these molecule
 s\, especially BMP-2.\nUseful References\nGarrison KR\, Donell S\, Ryder J
 \, Shemilt I\, Mugford M\, Harvey I\, Song F. Clinical effectiveness and c
 ost-effectiveness of bone morphogenetic proteins in the non-healing of fra
 ctures and spinal fusion: a systematic review. Health Technology Assessmen
 t 2007\; 11(30):1-150.\nMcAteer H\, Griffin D\, Donell S\, Scammell B\, Ko
 n E\, Stirling A\, Lilford R. The Current Clinical Opportunities for Regen
 erative Medicine in Bone. Scoping Report University of Birmingham 2007 Hww
 w.pcpoh.bham.ac.uk/publichealth/methodology/docs/health_economics/Scoping_
 Report_Bone.pdf
LOCATION:Cripps Court\, Magdalene College
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