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SUMMARY:Tissue Engineering of the Musculoskeletal System - Prof Ioannis Ya
 nnas\, MIT
DTSTART:20081013T140000Z
DTEND:20081013T143000Z
UID:TALK14550@talks.cam.ac.uk
CONTACT:Meera Arumugam
DESCRIPTION:Professor Ioannis Yannas is the Professor of Mechanical and Bi
 ological Engineering\, Massachusetts Institute of Technology. Work in his 
 laboratory led to discovery in the period 1975-82 of the first methodology
  for inducing organ regeneration in adults (regenerative medicine). The me
 thodology of regenerative medicine is currently based on grafting of scaff
 olds with regenerative activity at the site of a seriously injured organ i
 n adults. An active scaffold blocks contraction at the injured site and di
 rects synthesis of the injured stroma. Regeneration of epithelial tissues 
 and basement membrane follows spontaneously after the stroma has been rege
 nerated. Active scaffolds have so far been based on highly porous analogs 
 of the extracellular matrix\, possessing structural determinants of regene
 rative activity that have been identified. So far the adult organs that ha
 ve been induced to regenerate partially include skin\, the conjunctiva and
  peripheral nerves. Perfect regeneration has not been achieved. Similariti
 es and differences between induced organ regeneration in adults and early 
 foetal regeneration\, which occurs spontaneously and appears to be perfect
 \, have been detected. The paradigm of regenerative medicine has had its f
 irst clinically useful product with IntegraTM\, approved by the FDA in 199
 6\, a scaffold that is currently used to regenerate the dermis in patients
  with massive burns\, patients undergoing plastic and reconstructive surge
 ry of the skin\, and patients with chronic skin ulcers.
LOCATION:Cripps Court\, Magdalene College
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