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SUMMARY:Host immune responses in models of pneumococcal nasopharyngeal car
 riage and acute respiratory infection - Aras Kadioglu\, Department of Infe
 ction\, Immunity and Inflammation\, University of Leicester
DTSTART:20081112T163000Z
DTEND:20081112T173000Z
UID:TALK14612@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Streptococcus pneumoniae (the pneumococcus) is the most common
  bacterial respiratory pathogen in the United Kingdom\, causing pneumonia\
 , septicaemia and meningitis. The pneumococcus is responsible for between 
 60-75% of community acquired pneumonia in the UK\, resulting in mortality 
 rates of over 20% for those with concurrent pneumococcal septicaemia. Worl
 dwide\, the situation is worse\, with pneumococcal septicaemia the major c
 ause of infant mortality in developing countries\, causing approximately 2
 5% of all preventable deaths in children under the age of 5\, and an annua
 l burden of over 1.2 million infant deaths. The pneumococcus is particular
 ly well adapted to colonising the mucosal surfaces of the nasopharynx and 
 the combination of bacterial virulence factors\, together with the ability
  to evade early host immune components\, allows the pneumococcus to spread
  from the upper respiratory tract to sterile regions of the lower respirat
 ory tract\, leading to pneumonia. In this seminar we shall discuss in vivo
  models of long-term nasopharyngeal carriage and models of acute and chron
 ic pneumonia. The role of virulence factors such as pneumolysin will be di
 scussed as will the response of host immunity to such events. 
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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