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SUMMARY:Computational analysis of the connection between cell cycle and ci
 rcadian rhythm - Judit Zámborszky\, CoSBi
DTSTART:20081021T130000Z
DTEND:20081021T140000Z
UID:TALK14740@talks.cam.ac.uk
CONTACT:Dr Fabien Petitcolas
DESCRIPTION:*Abstract*: Cell cycle and circadian rhythms are conserved bio
 logical processes with robust cyclic features. The interactions between th
 ese two oscillators are objective of active research. Cell division cycle 
 seems to be gated by circadian clock\, possibly by the clock transcription
  factor (BMAL1/CLK) induced cell cycle kinase\, WEE1. On the other hand\, 
 a clock component (i.e. FRQ in _Neurospora crassa_ and mPer1 in mouse) is 
 phosphorylated by cell cycle kinase\, CHK2\, upon DNA damage. These data i
 ndicate that there are bi-directional interactions between the cell cycle 
 and the circadian clock. The reasons for the links remain unclear.\nWe bui
 ld computational models to understand how a molecular interaction network 
 determines the experimentally observed physiology of these biological syst
 ems. Starting from the biological problem\, I will describe the methods we
  used to investigate the importance and results of connection between thes
 e two fundamental biological systems.\n\n*Biography*: Judit Zámborszky at
 tended the Faculty of Chemical Technology and Biotechnology at the Budapes
 t University of Technology and Economics. She received an M.S. degree in B
 ioengineering in 2007 (thesis title: “Connection between the cell cycle 
 and the circadian rhythm in mammalian cells”) under the guidance of Atti
 la Csikász-Nagy. In 2004 she began to work with mathematical modeling in 
 the Molecular Network Dynamics Research Group\, led by Professor Béla Nov
 ák. She started her current research on cell cycle and circadian rhythm m
 odeling with deterministic and stochastic approaches in 2005\, working wit
 h Attila Csikász-Nagy and Christian I. Hong (Dartmouth College\, USA). In
  2007 she won first prize in Bioinformatics at the National Scientific Stu
 dent Conference of Hungary in Biological Sciences. The focus of her work w
 as to build and couple models by writing ordinary differential equations f
 or the interactions in the regulatory network and analyze these two basic 
 and important oscillating endogenous devices by computational simulations\
 , phase-plane portraits\, bifurcation diagrams and other methods.
LOCATION:Small public lecture room\, Microsoft Research Ltd\, 7 J J Thomso
 n Avenue (Off Madingley Road)\, Cambridge
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