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SUMMARY:Dynamics of cell cycle transitions - Attila Csikasz-Nagy\, CoSBi
DTSTART:20090422T100000Z
DTEND:20090422T110000Z
UID:TALK14753@talks.cam.ac.uk
CONTACT:Dr Fabien Petitcolas
DESCRIPTION:*Abstract*: The eukaryotic cell cycle is distributed into four
  phases (G1\, S\, G2\, M). The transitions between these phases control im
 portant cell cycle events like DNA replication\, mitosis and cell division
 . These processes have to happen in correct order and only once per cell c
 ycle. The special dynamics of the underlying molecular network is responsi
 ble to make these transitions irreversible. Positive feedback regulations 
 ensure that the transitions happen only once and feed-forward loops determ
 ine the correct timing of these events. The details of these molecular reg
 ulatory loops and the intricacy of their dynamics will be presented.\n\n*R
 eferences*:\n* Novak B\, Tyson JJ\, Gyorffy B\, Csikasz-Nagy A. Irreversib
 le cell-cycle transitions are due to systems-level feedback\, Nat Cell Bio
 l 2007\; 9:724-728.\n* Csikasz-Nagy A\, Kapuy O\, Toth A\, Pal C\, Jensen 
 LJ\, Uhlmann F\, Tyson JJ\, Novak B. Cell cycle regulation by feed-forward
  loops coupling transcription and phosphorylation. Mol Sys Biol 2009\; in 
 press. \n\n*Biography*: Short bio \nAttila Csikász-Nagy was born in Budap
 est\, Hungary on 20 June 1974. He received an M.S. degree in 1998 (thesis 
 title: “Mathematical models for the evolution of eukaryotic cell cycle
 ”)\, and a PhD degree in 2000 (thesis title: “Mathematical models of t
 he budding yeast cell cycle”) from the Budapest University of Technology
  and Economics under the guidance of Prof. Béla Novák. He spent several 
 months in 1997 and 1999 as a visiting scholar in Prof. John Tyson’s lab 
 (Virginia Tech\, USA)\, modeling the Start and exit-of-mitosis transitions
  of the budding yeast cell cycle. The focus of his graduate work was study
 ing how various eukaryotic cells control their cell cycle progression in t
 ime\, using coupled ordinary differential equations (ODE) and bifurcation 
 analyses. Since the process of cell growth and division is orchestrated in
  space as well as in time\, Attila became interested in how fission yeast 
 cells obtain their rod shape\, grow in a polarized fashion (they first gro
 w in one end and then switch to grow in both ends) and then make a septum 
 in the middle. From 2000-2004\, he worked with Dr. Novák as a postdoctora
 l fellow to study microtubule dynamics and morphogenesis in fission yeast\
 , using reaction-diffusion equations. In 2004\, he spent a year as a postd
 octoral fellow with Dr. Tyson to build a generic model of cell cycle regul
 ation that is applicable to a wide spectrum of eukaryotes from budding yea
 st\, fission yeast\, and Xenopus embryos up to mammalian cells. In 2005\, 
 he joined the Molecular Network Dynamics Research Group of the Hungarian A
 cademy of Sciences\, led by Béla Novák. He was an assistant professor fr
 om 2005-2007 at the Budapest University of Technology and Economics\, wher
 e he taught courses in cell biology and microbial physiology. During his c
 areer\, Attila worked out mathematical models of cell cycle regulation in 
 various eukaryotic organisms and analyzed these models with tools of non-l
 inear dynamics. His publications have appeared in leading journals of the 
 field\, and Attila is a regular reviewer for journals such as the Journal 
 of Theoretical Biology\, Molecular Systems Biology\, BMC Systems Biology\,
  Physical Review Letters\, PLoS Computational Biology\, IET Systems Biolog
 y and other related journals. Attila joined CoSBi in June 2007. 
LOCATION:Small public lecture room\, Microsoft Research Ltd\, 7 J J Thomso
 n Avenue (Off Madingley Road)\, Cambridge
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