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SUMMARY:Supramolecular arsenal of adaptive and natural killers - Prof. Mic
 hael Dustin\; Professor of Immunology and Wellcome Principal Research Fell
 ow\, Director of Research - Kennedy Institute\, University of Oxford
DTSTART:20200731T120000Z
DTEND:20200731T130000Z
UID:TALK149821@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:CD8 T cells and natural killer (NK) cells play an important ro
 le in defense against viral infection and cancer. Both cell types use mult
 iple cytotoxic pathways to kill infected or deranged host cells and can al
 so directly target bacteria and parasites. In this talk I will discuss thr
 ee stories related to how CD8 T cells establish cytotoxic of inhibitory im
 munological synapses. The first story relates to effector mechanisms utili
 zed by CD8 T cells and NK cells with supramolecular assemblies based on 10
 0 nm particles. Which cytotoxic mechanisms are deployed is tactical and ba
 sic on what target-associated receptors are present. FAS on targets trigge
 red extracellular vesicles with FasL\, whereas 100 nm protein “bombs” 
 with a core of perforin and granzymes and a shell of thrombospondin-1 were
  deployed when the target expressed ICAM1. We refer to these protein bombs
  as supramolecular attack particles\, which are made by CD8 T cells and NK
  cells. Adhesion molecules like ICAM1 and CD58 establish the immunological
  synapse. I will describe how CD2 contributes to signal amplification in s
 ynapses and how CD2 expression is low in TILs in several types of cancer. 
 Finally\, I will discuss how malaria parasites use some members of a large
  family of proteins called RIFINs to inhibit attack by NK cells-shifting t
 he activating immune synapse to an inhibitory immune synapse to protect pa
 rasitized red blood cells.\n\nJoin Zoom Meeting:\n\nhttps://zoom.us/j/9406
 0340861?pwd=MWpGcmUwWVFRV0ZMM0dGVk1Ua01mQT09\n\nMeeting ID:        940 603
 4 0861\nPassword:           397600
LOCATION:Zoom Seminar
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