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SUMMARY:Questions around cellular plasticity:  naive pluripotency and epig
 enetic rejuvenation by reprogramming - Prof. Manuel Serrano\; ICREA Profes
 sor\, Institute for Research in Biomedicine (IRB Barcelona)\, Spain
DTSTART:20200715T110000Z
DTEND:20200715T120000Z
UID:TALK149848@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:My lab has a general interest in cell plasticity\, how it is r
 egulated\, and its beneficial or maladaptive implications. I will present 
 two recent projects.  First\, I will talk about how the transcriptional ma
 chinery regulates cellular plasticity.  We have identified an actionable k
 inase\, CDK8\, and we show that chemical inhibition of CDK8 reinforces enh
 ancers and thereby cell identity\, resulting in a loss of plasticity.  We 
 apply this to solve a long-standing problem that is the stabilisation of h
 uman pluripotent stem cells in their naïve state.  Then\, I will present 
 our data in collaboration with the laboratory of Wolf Reik on the use of t
 he Yamanka factors to trigger plasticity in vivo in a regulated manner.  I
  will show that transient in vivo expression of the Yamanaka factors induc
 es epigenetic rejuvenation of tissues.\n\n\nJoin us:\nhttps://zoom.us/j/97
 446595226?pwd=NkZNTkg3V3d0UEszQ0gyKzRFVm9HZz09\n \nMeeting ID: 974 4659 52
 26\nPassword: 014403
LOCATION:Zoom Seminar
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