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SUMMARY:Profiling and understanding Ras variant biology - Prof. Ian Prior\
 ; NWCR Chair of Molecular Oncology\, Head of the Division of Molecular Phy
 siology &amp\; Cell Signalling\, Institute of Systems\, Molecular &amp\; I
 ntegrative Biology\, University of Liverpool
DTSTART:20200721T110000Z
DTEND:20200721T120000Z
UID:TALK149854@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Ras GTPases are important hubs in signalling networks that reg
 ulate cell proliferation and survival. Ras pathway nodes are commonly muta
 ted in developmental disorders and cancers\; and Ras mutants are found in 
 ~20% of all cancer patients. Cells express four closely related isoforms o
 f Ras called HRAS\, KRAS4A\, KRAS4B and NRAS. Ras isoforms and different a
 ctivating Ras mutations differentially contribute to normal and disease as
 sociated Ras biology\; however\, the mechanisms underpinning these observa
 tions are poorly understood. I’ll be discussing our recent work investig
 ating Ras variant biology to try to understand how they differ and why KRA
 S is so oncogenic. Using models to probe endogenous Ras biology we find th
 at Ras variant outputs are context dependent and do not conform to the pre
 vailing dogma derived from over-expression studies.\n\nJoin Us:\nhttps://z
 oom.us/j/99180190889?pwd=ekd0SUNaNTUvbTk1NTRyTWhyZlJjZz09\n\nMeeting ID: 9
 91 8019 0889\nPassword: 836272
LOCATION:Zoom Seminar
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