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SUMMARY:Ying and Yang of G-quadruplxes for genome stability - Prof. Katrin
  Paeschke\; University Hospital Bonn (UKB)\, Germany 
DTSTART:20200807T110000Z
DTEND:20200807T120000Z
UID:TALK149857@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:In recent years accumulating evidence arose that DNA can fold 
 into an alternative secondary structure named G-quadruplex (G4). Due to th
 e specific location of G4 structures within the genome and their stability
  they can influence cellular processes such as transcription1. Contrary to
  their regulatory potential G4 structures also challenge genome stability 
 by blocking DNA replication\, enhancing recombination and increasing the f
 requencies of mutations and deletions1. In the last years different strate
 gies have been used to specifically target G4 structures using chemical G4
  ligands to reduce the proliferation of cancer cells2. We aim to use diffe
 rent genetic and molecular analysis to identify novel G4 binding proteins 
 which will give raise to the relevance of G4 formation for genome stabilit
 y.\n\nJoin us:\nhttps://zoom.us/j/95797510141?pwd=K1E0N1Qvb0ZWb1lGTjhicjAx
 K0tRdz09\n \nMeeting ID: 957 9751 0141\nPassword: 663635
LOCATION:Zoom Seminar
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