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SUMMARY:The protein kinase DYRK2 as a new regulator of protein homeostasis
  - Dr Laureano de la Vega\; CRUK Fellow and Group Leader\, School of Medic
 ine\, Division of Cellular Medicine\, University of Dundee
DTSTART:20200812T110000Z
DTEND:20200812T120000Z
UID:TALK149872@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Cancer cells are exposed to high levels of cellular stress and
  they depend on stress-relief pathways in order to survive and proliferate
 . To survive the proteotoxic stress produced by the accumulation of excess
  and often misfolded proteins\, cancer cells can either a) increase protei
 n folding capacity (controlled by the transcription factor HSF1) or b) inc
 rease protein degradation (by the autophagy and ubiquitin proteasome syste
 m). In this talk I will show how in triple negative breast cancer (TNBC) c
 ells\, the dual-specificity tyrosine-regulated kinase 2 (DYRK2) is an ups
 tream positive regulator of both HSF1 and the proteasome. This presents DY
 RK2 as a positive regulator of two main mechanisms by which aneuploid cell
 s adapt\, survive and become malignant\, and thus highlights this kinase a
 s a potential therapeutic target.\n\n\nJoin Us:\nhttps://zoom.us/j/9745797
 3301?pwd=ZjBqaW4zZXhsVSsvNXJOMklvVXR6QT09\n\nMeeting ID:                  
      974 5797 3301\nPassword:                          596384\n
LOCATION:Zoom Seminar
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