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SUMMARY:Native ambient mass spectrometry: Latest developments for in situ 
 protein analysis - Prof. Helen J. Cooper\; Professor of Mass Spectrometry\
 , School of Biosciences\, University of Birmingham
DTSTART:20201104T120000Z
DTEND:20201104T130000Z
UID:TALK150238@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Growing evidence suggests in situ protein analysis\, i.e.\, di
 rectly from the physiological environment\, has great potential for biomar
 ker discovery\, diagnosis & early detection of disease\, targeting therape
 utics (personalised medicine) and assessment of therapeutic efficacy. Mass
  spectrometry imaging (MSI) provides information on the spatial distributi
 on of molecules within a biological substrate without the requirement for 
 labelling. Its broad specificity\, i.e.\, the capability to spatially prof
 ile any analyte ion detected\, constitutes a major advantage over other im
 aging techniques. A separate branch of mass spectrometry\, native mass spe
 ctrometry\, provides information relating to protein structure through ret
 ention of solution-phase interactions in the gas-phase. Our research focus
 es on combining the benefits of MSI and native MS\, i.e.\, to obtain infor
 mation on both spatial distribution and tertiary or quaternary structure\,
  through native mass spectrometry imaging (native MSI).\n\nProfessor Helen
  J. Cooper is an expert in the gas-phase ion chemistry of peptides and pro
 teins. She is a world-leader in the field of electron capture dissociation
  mass spectrometry and is responsible for establishing the University of B
 irmingham as a centre of excellence in mass spectrometry research. Profess
 or Cooper has published extensively in peer-reviewed journals and serves o
 n a number of national and international committees including the Editoria
 l Board for the Journal of the American Society for Mass Spectrometry and 
 the British Mass Spectrometry Society.\n\nPlease click the link below to j
 oin the webinar:\nhttps://zoom.us/j/99225785134\n
LOCATION:Zoom webinar
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