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SUMMARY:Evolved minimal frustration - How multiple functions are encoded i
 n biomolecules - Dr Konstantin Röder\, University of Cambridge
DTSTART:20201118T143000Z
DTEND:20201118T153000Z
UID:TALK150316@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:The fast and reliable folding of proteins has been described a
 s a consequence of the principle of minimal frustration [1]\, leading to t
 he commonly employed description of folding based on folding funnels [2]. 
 Importantly\, this description may be extended to nucleic acids [3]\, and 
 forms part of our understanding of any molecular in terms of energy landsc
 apes [4]. While only a single funnel on the potential energy landscape is 
 required to allow for fast folding\, a number of systems do not conform wi
 th this simple description. Exploration of the energy landscapes for these
  systems show landscapes exhibiting multiple funnels associated with disti
 nct functions. This observation might be understood as an extension to the
  principle of minimal frustration\, as landscapes will exhibits the number
  of funnels required to fulfil multiple functions [5]. These multifunction
 al systems can be manipulated using small perturbations\, such as sequence
  mutations [6].\n\nIn this talk\, I will present recent algorithmic advanc
 es that allow the study of these biological systems\, discuss a number of 
 example systems\, and highlight how computational approaches lead to an im
 proved understanding of biological systems and offer explanations for expe
 rimental observations.\n\n[1] Bryngelson and Wolynes\, PNAS\, 1987\n[2] Le
 opold\, Montal and Onuchic\, PNAS\, 1992\n[3] (a) Thirumalai\, PNAS\, 1998
 \; (b) Chen and Dill\, RNAS\, 2000\n[4] "Energy landscapes"\, Wales\, CUP\
 , 2003\n[5] Röder and Wales\, JPCB\, 2018\n[6] (a) Röder and Wales\, JCT
 C\, 2017\; (b) Röder and Wales\, Biochemistry\, 2018\; (c) Röder et al\,
  NAR\, 2020\n
LOCATION:Zoom Meeting ID: 928 9045 3974 Passcode: 313781
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