BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Genome regulation by ATP-dependent chromatin remodeling and phase-
 separation - Professor Geeta Narlikar\, University of California\, San Fra
 ncisco
DTSTART:20210506T160000Z
DTEND:20210506T170000Z
UID:TALK150550@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Our group is interested in understanding the biophysical mecha
 nisms underlying chromatin regulation. Towards this goal we study how chro
 matin remodeling machines work and how heterochromatin functions. In my ta
 lk I will share two sets of findings\, one in each of these two areas. In 
 the context of chromatin remodeling\, I will describe how INO80\, a conser
 ved remodeling machine shows a substantial preference for sliding subnucle
 osomal particles over complete nucleosomes. These findings may explain how
  subnucleosomal particles are repositioned in cells in the wake of transcr
 iption and other disruptive processes. In the context of heterochromatin\,
  I will describe how a pool of weakly bound heterochromatin proteins capit
 alize on the polymer properties of DNA to produce phase-separated domains 
 that are simultaneously resistant to large forces and susceptible to compe
 tition by other molecules. I will use these and other results to propose t
 hat phase-separation confers biologically useful properties to heterochrom
 atin.
LOCATION:Zoom meeting
END:VEVENT
END:VCALENDAR