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SUMMARY:Genomic Scope of Adaptive Mutations in the Face of Environmental C
 hallenges - Dr Sally Otto\, Department of Zoology\, University of British 
 Columbia\, Vancouver 
DTSTART:20210128T160000Z
DTEND:20210128T170000Z
UID:TALK150565@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:As evolutionary biologists\, we are only now getting a clear\n
 picture of the genetic basis of adaptation.  Through genomic sequencing\,\
 nwe can pinpoint the mutations responsible for adaptation and use these\nm
 utations to parameterize models and to test evolutionary theory\,\nprovidi
 ng a much sounder empirical basis for this theory.  In this talk\, I\nwill
  describe experiments with Saccharomyces cerevisiae aimed at\nclarifying t
 he nature and distribution of beneficial mutations.  A panel\nof independe
 nt adaptive mutations was obtained by exposing haploid yeast\nto harsh env
 ironmental conditions: a fungicide (nystatin) or toxic levels\nof copper. 
 The array of mutations allowing adaptation to the either\nenvironment was 
 determined by genome-wide sequencing of 35 different\nadapted lines from e
 ach of the two environments. This panel was then used\nto measure trade-of
 fs among environments and among ploidy levels\, as well\nas properties suc
 h as dominance across environments. The implications for\nHaldane's sieve\
 , the role of ploidy in adaptation\, and speciation will be\ndiscussed.\n
LOCATION:Zoom meeting
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