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SUMMARY:Molecular and evolutionary processes generating variation in gene 
 expression - Dr Patricia Wittkopp\, Biological Science Building\, Universi
 ty of Michigan
DTSTART:20210218T140000Z
DTEND:20210218T150000Z
UID:TALK150568@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Genetic variation affecting gene expression is wide-spread wit
 hin and among species. This variation reflects the combined actions of mut
 ation introducing new genetic variants and selection eliminating deleterio
 us ones. Comparative studies of gene expression in fruit flies\, yeast\, p
 lants\, and mice have shown that the relative contributions of cis- and tr
 ans-acting variants to expression differences change over evolutionary tim
 e\, indicating that selection has different effects on cis- and trans-regu
 latory variants. To better understand the reasons for this now widely obse
 rved pattern\, we have been systematically studying the effects of mutatio
 n and selection on expression of the TDH3 gene of the baker’s yeast Sacc
 haromyces cerevisiae. This work has revealed differences between cis- and 
 trans-regulatory mutations in their frequency\, effects\, and dominance. D
 ifferences in pleiotropy are also generally assumed to exist between cis- 
 and trans-regulatory that affect their evolutionary fate\, but have been d
 ifficult to measure. In this talk\, I will discuss how newly arising cis- 
 and trans-regulatory mutations affecting expression of this focal gene are
  structured within the regulatory network\, their pleiotropic effects on e
 xpression of all other genes in the genome\, and how these pleiotropic eff
 ects influence fitness.
LOCATION:Zoom meeting
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