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SUMMARY:Defining intrinsic determinants of regeneration ability and inabil
 ity. - Professor Elly Tanaka\, IMP - Research Institute of Molecular Patho
 logy\, Vienna 
DTSTART:20210211T133000Z
DTEND:20210211T143000Z
UID:TALK150643@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Among tetrapods\, the salamanders show a remarkable ability to
  regenerate complex body parts\nincluding the limb where the entire\, patt
 erned limb skeleton and all other tissues are faithfully\nreconstructed af
 ter limb amputation. In contrast\, the frog shows only partial regeneratio
 n of a\ncartilage rod\, and mammals show no limb regeneration except the v
 ery tip of the digit. We have been\nusing molecular biology and protein bi
 ochemistry approaches to define the extracellular cues that\ninduce limb r
 egeneration. While in most cases\, orthologous signalling proteins show ho
 mologous\nfunction\, it appears that one important initiating molecule\, M
 ARCKS-Like Protein\, shows species\nspecific activities. I will discuss ou
 r work on this protein. We have also turned to single cell sequencing\nto 
 understand the molecular progression of regeneration in the axolotl\, and 
 to compare the cell states\nthat occur to those in abortive frog regenerat
 ion. Through combination of transcriptome analysis and\ncell transplantati
 on\, we have asked whether the limitation in frog regeneration is due to h
 umoral\,\nsystemic factors or due to intrinsic limitation in limb cell pot
 ential.
LOCATION:Zoom meeting
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