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SUMMARY:System-level analysis of salmonella metabolism during infection - 
 Prof. Dr. Dirk Bumann\, Biozentrum\, Focal Area Infection Biology\, Univer
 sity Basel\, Switzerland
DTSTART:20081113T163000Z
DTEND:20081113T173000Z
UID:TALK15091@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Infectious diseases represent a major worldwide threat to huma
 n health. Host-pathogen interactions are understood at increasing molecula
 r detail but translation of this knowledge into novel strategies to combat
  infectious disease has remained difficult. Specifically\, the dramatic de
 cline in development of novel antimicrobials over the last 20 years is lik
 ely to substantially reduce treatment options in the near future. One pote
 ntial reason why it is so difficult to translate basic research results to
  effective control strategies\, could be the prevailing focus on the actio
 n of individual pathogen or host components. Instead\, system-level analys
 is of interacting host/pathogen networks might be required for rational de
 velopment of novel effective control strategies. We are studying metabolic
  host-pathogen interactions as a particularly suitable model for establish
 ing approaches for system-level analysis of infectious diseases. Specifica
 lly\, we are reconstructing Salmonella metabolism in infected mice based o
 n large-scale proteomics and mutant phenotype data. We are interpreting th
 ese data using in silico quantitative metabolic modeling. Our results reve
 al a marked robustness of Salmonella metabolism during infection thus limi
 ting potential targets for novel antimicrobials. Multiple mutations and pe
 rturbations of the host-pathogen nutritional interface reveal several fact
 ors that contribute to this high robustness\, and indicate potential strat
 egies to break redundancy with drug combinations. Our ultimate goal is an 
 integrated quantitative model of metabolic Samonella-host interactions dur
 ing infection.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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