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SUMMARY:Taking control of innate immunity with nanobiologics - Willem Muld
 er\, Icahn School of Medicine at Mount Sinai\, New York
DTSTART:20201105T123000Z
DTEND:20201105T133000Z
UID:TALK151084@talks.cam.ac.uk
CONTACT:47770
DESCRIPTION:Immunotherapy is revolutionizing the treatment of diseases. Mo
 st of the immunotherapy strategies currently being developed engage the ad
 aptive immune system. In recent years\, emerging evidence has shown that t
 he innate immune system displays long-term changes in its functional progr
 am through metabolic and epigenetic programming of myeloid cells (monocyte
 s\, macrophages\, dendritic cells). Therefore\, targeting myeloid cells an
 d their progenitors is a powerful ‘therapeutic framework’ to regulate 
 the delicate balance of immune homeostasis\, priming/training and toleranc
 e. This Presentation will showcase how nanobiologic-based immunotherapies 
 can be applied to achieve long-term therapeutic benefits in detrimental di
 seases\, including cancer and cardiovascular diseases as well as to preven
 t organ rejection after transplantation. In addition\, a translational wor
 kflow involving innovative multimodality imaging approaches and large anim
 al models will be discussed.
LOCATION:Zoom Webinar ask for details vr314@medschl.cam.ac.uk
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