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SUMMARY:Characterizing and forecasting tumour evolution - Dr Robert Noble 
 from City\, University of London
DTSTART:20200928T093000Z
DTEND:20200928T103000Z
UID:TALK151540@talks.cam.ac.uk
CONTACT:Anna Toporska
DESCRIPTION:Characterizing the mode – the way\, manner\, or pattern – 
 of evolution in tumours is important for clinical forecasting and optimizi
 ng cancer treatment. DNA sequencing studies have inferred various modes\, 
 including branching\, punctuated and neutral evolution\, but it is unclear
  why a particular pattern predominates in any given tumour. Dr Robert Nobl
 e will argue that differences in tumour architecture can explain the varie
 ty of observed genetic patterns. He will present results of spatially expl
 icit population genetic models showing that\, within biologically relevant
  parameter ranges\, human tumours are expected to exhibit four distinct on
 co-evolutionary modes (oncoevotypes)\, governed by the mode of cell disper
 sal and the range of cell-cell interaction. New quantitative indices will 
 be introduced for describing and classifying these oncoevotypes. Dr Noble 
 will further present an investigation of when\, why and how intratumour he
 terogeneity can be used to forecast tumour growth rate and progression-fre
 e survival. He will thus provide explanations – grounded in evolutionary
  theory – for empirical findings in various cancers. This work informs t
 he search for new prognostic biomarkers and contributes to the development
  of predictive oncology.
LOCATION:ZOOM (live)
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