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SUMMARY:Quality control of proteins orphaned in the cytosol - Ramanujan S 
 Hegde\, MRC LMB
DTSTART:20210520T120000Z
DTEND:20210520T130000Z
UID:TALK151585@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:A large proportion of the cell’s proteins must be segregated
  to membrane-bound organelles and multi-protein complexes. Failures in loc
 alization or assembly must be recognized by the cell and promptly degraded
  to avoid the accumulation of aberrant and potentially harmful proteins. O
 ur group has taken a biochemical strategy to identify cytosolic factors th
 at recognize mislocalized or unassembled proteins that we term orphans. We
  have used reconstitution approaches and experiments in mammalian cell cul
 ture to understand how they function. I will describe our ongoing efforts 
 to identify new chaperone-like factors that identify orphan proteins and s
 electively target them for degradation. These factors are likely to play c
 rucial roles in maintaining cytosolic protein homeostasis\, and when mutat
 ed\, may contribute to diseases of protein misfolding such as neurodegener
 ation. Conversely\, they may be particularly crucial for facilitating rapi
 d grow of mutation-ridden cancer cells in need to robust quality control s
 ystems.
LOCATION:https://zoom.us/j/96287903585?pwd=TTdwcEg4VkU0ZjQyTUVka2dDendjUT0
 9  Meeting ID: 962 8790 3585 Passcode: 571491
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