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SUMMARY:Decoding and Recoding the Opposing Roles of Interferon and Pattern
  Recognition Receptor Signaling in Cancer Immunotherapy - Andy J. Minn\, M
 D\, PhD\, Abramson Family Cancer Research Institute at the University of P
 ennsylvania
DTSTART:20211216T130000Z
DTEND:20211216T140000Z
UID:TALK151597@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Interferon (IFN) and pattern recognition receptor (PRR) signal
 ing are important for immune activation and the effectiveness of cancer im
 munotherapies. However\, these pathways can also have inhibitory roles due
  to entwined negative feedback mechanisms that can be exploited by tumors 
 often after chronic stimulation. I will discuss our findings on how these 
 opposing roles are regulated in cancer\, how they can contribute to immuno
 therapy resistance\, and approaches we are pursuing to mitigate the inhibi
 tory effects of IFN/PRR signaling.
LOCATION:Zoom
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