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SUMMARY:Defying Mendel’s laws: epigenetic insights from the sulfurea par
 amutation in Solanum Lycopersicum - Claudia Dos Santos Martinho\, Baulcomb
 e group
DTSTART:20201105T130000Z
DTEND:20201105T140000Z
UID:TALK152326@talks.cam.ac.uk
CONTACT:85030
DESCRIPTION:Gene silencing events can distort meiotically heritable epigen
 etic responses by altering gene expression without involving changes in DN
 A sequences. Paramutation is such a gene silencing process\, found across 
 kingdoms\, that involves the trans silencing of an active (paramutable) al
 lele caused by a silent (paramutagenic) allele. The silent-state of the pa
 ramutable allele is heritable and this allele can become paramutagenic in 
 subsequent generations thereby altering Mendelian patterns of inheritance.
  The establishment and maintenance of paramutation has been mostly explain
 ed by models invoking small RNA\n(sRNA) mediated silencing to explain the 
 transfer of epigenetic marks between homologue chromosomes.\n\nThis talk w
 ill address a particular case of paramutation\, the sulfurea (sulf) allele
 \, which is a silent and paramutagenic epigenetic variant of a tomato (Sol
 anum lycopersicum cv Lukullus) gene involved in chlorophyll synthesis. Usi
 ng genetic analysis\, sRNA sequencing\, chromatin conformation capture (Hi
 C/4C) in chlorotic leave tissues\, I will discuss the molecular mechanism 
 underlying the maintenance of paramutation.\n\n\nContact se389@cam.ac.uk f
 or the Zoom link if you are not on our mailing list.
LOCATION:Online
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