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SUMMARY:Assembling and recombining the Arabidopsis centromeres - Matthew N
 aish\, Henderson Group
DTSTART:20201126T130000Z
DTEND:20201126T140000Z
UID:TALK152332@talks.cam.ac.uk
CONTACT:85030
DESCRIPTION:Every eukaryotic chromosome has a centromere (a locus responsi
 ble for poleward movement at mitosis and meiosis) and while the function i
 s highly conserved\, the form and structure of the underlying DNA sequence
  can vary dramatically between species.\n\nThe ‘centromere paradox’ is
  that despite this conserved function\, many essential centromeric protein
 s\, the chromosomal location or DNA sequence have been reported to be able
  to evolve rapidly\, with incompatibilities between centromeric components
  thought to be one mechanism of establishing reproductive isolation of eme
 rging species. In addition\, this rapid evolution occurs despite the fact 
 the centromeric region are highly suppressed for crossover events in many 
 species.\n\nRecent advances in long read DNA sequencing provide an opportu
 nity to map and understand the structure of centromeres for the first time
 . This talk will present work from our ongoing project to utilise Nanopore
  sequencing to map across the Arabidopsis thaliana centromeres\, investiga
 te the genetic and epigenetic landscape of these regions and to identify f
 actors affecting centromeric recombination and evolution.\n\nContact recep
 tion@plantsci.cam.ac.uk for a Zoom link prior to a talk if you are not on 
 our mailing list. Due to having to go onine\, we are restricting the talks
  to University of Cambridge and alumni to keep them as informal as possibl
 e.
LOCATION:Online
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