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SUMMARY:Senescence Lifecycle in cancer and ageing - Dr Masashi Narita\; Gr
 oup Leader\, Cancer Research UK Cambridge Institute
DTSTART:20201118T150000Z
DTEND:20201118T160000Z
UID:TALK152353@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Cellular senescence is a fate-determined state in response to 
 stress\, involving diverse effector mechanisms\, such as autophagy activat
 ion\, epigenetic and high-order chromatin structure alterations and activa
 tion of a secretory program. Through the senescence-associated secretory p
 henotype (SASP)\, senescent cells actively communicate with their surround
 ings and the immune system\, having a profound impact on the tissue microe
 nvironment. This is a dynamic and progressive process\; the timely control
  of the SASP and senescence resolution is critical for tissue homeostasis.
  I will introduce the view that the proper execution of a senescence lifec
 ycle is critical for the physiological role of senescence\, whereas senesc
 ence-associated pathologies may be a consequence of a deviation from an in
 tact senescence lifecycle (see our recent review PMID 30709901). Underlyin
 g mechanisms of senescence functionality (or the SASP)\, with emphasis on 
 epigenetics and autophagy\, will be discussed. \n\n\nPlease click the link
  below to join the webinar: https://zoom.us/j/98394964278
LOCATION:Zoom webinar
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