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SUMMARY:Epigenetic regulation\, heterochromatin and anti-fungal resistance
  - Prof. Robin Allshire\; Professor of Chromosome Biology\, Wellcome Centr
 e for Cell Biology\, Institute of Cell Biology\, University of Edinburgh
DTSTART:20201125T150000Z
DTEND:20201125T160000Z
UID:TALK152356@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Robin Allshire\, Professor of Chromosome Biology\, University 
 of Edinburgh. 1981-1985: PhD MRC Mammalian Genome Unit\, Edinburgh with Ed
  Southern. 1985-89: Postdoc with Nick Hastie\, MRC Human Genetics Unit\, E
 dinburgh. 1989-1990: Independent Researcher\, CSHL\, NY. 1990-2002: tenure
 d scientist MRC Human Genetics Unit\, Edinburgh. 2002-present: Wellcome Tr
 ust Centre for Cell Biology\, University of Edinburgh. Elected EMBO member
  1998\; Wellcome Trust Principal Research Fellowship 2002-present\; Electe
 d fellow of the Royal Society of Edinburgh 2005\, the Royal Society\, Lond
 on 2011\, the Academy of Medical Sciences 2020\; awarded Genetics Society 
 Medal 2013. Has served on CRUK\, EMBO and Wellcome Trust funding committee
 s and was Chair of the Wellcome Trust/Royal Society Sir Henry Dale Fellows
 hip Committee 2014-17. He is a trustee of the Darwin Trust of Edinburgh 20
 13-present. \n\nResearch: \nHe first demonstrated that fission yeast centr
 omeres contain heterochromatin and went on to demonstrate that this hetero
 chromatin plays a pivotal role in ensuring sister-centromere cohesion\, pr
 omoting CENP-A chromatin and thus\, kinetochore assembly. His team found t
 hat histone H3 lysine 9 methylation can act as a bona fide epigenetic mark
  allowing the transmission of information though cell division. Recently t
 hey discovered that this epigenetic mechanism allows fungi to develop resi
 stance to antifungal drugs without alterations to their DNA. This finding 
 is important for understanding how pathogenic fungi become resistant to th
 e limited number of available antifungal agents in both clinical and agric
 ultural arenas. \n\nZoom link:\nhttps://zoom.us/j/95055078842\n
LOCATION:Zoom webinar
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