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SUMMARY:Hopfield barriers: following the energy in cellular information pr
 ocessing - Jeremy Gunawardena (Harvard Medical School)
DTSTART:20201124T130000Z
DTEND:20201124T140000Z
UID:TALK152548@talks.cam.ac.uk
CONTACT:Patrick Pietzonka
DESCRIPTION:Zoom link: https://maths-cam-ac-uk.zoom.us/j/94018037756\n\n\n
 It has long been understood that energy dissipation is fundamental to life
  and we know a great deal about the molecular components which acquire and
  transduce energy. The role of energy dissipation in force generation and 
 directed movement is well understood but its role in information processin
 g has been much less well studied. We will draw inspiration from John Hopf
 ield's classic analysis of kinetic proofreading to suggest the broader pri
 nciple that any cellular information processing task has a performance lim
 it set by thermodynamic equilibrium. We describe such Hopfield barriers in
  the context of gene regulation and discuss the challenges of "following t
 he energy" to disentangle how energy dissipation away from equilibrium giv
 es rise to information processing functionality.
LOCATION:via zoom\, meeting ID 940-1803-7756
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