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SUMMARY:Role of medial prefrontal cortex serotonin 2A receptors in recogni
 tion memory in rodents - Professor Noelia Weisstaub\, Faculty of Exact and
  Natural Sciences of the University of Buenos Aires
DTSTART:20201106T163000Z
DTEND:20201106T180000Z
UID:TALK152623@talks.cam.ac.uk
CONTACT:Louise White
DESCRIPTION:Episodic memories contain information about our personal exper
 iences. But memories would be useless if we could not retrieve them. Memor
 y retrieval requires the correct selection of a particular trace to be exp
 ressed. However\, many memories share cues\, so how does the brain control
  interference between similar memories during retrieval? A system includin
 g the medial Prefrontal Cortex (mPFC) has been proposed to mediate respons
 e selection and control interference. Over the years we have studied how s
 erotonin and particularly 5-HT2a receptors \n (5-HT2aR) modulates memory p
 rocesses. By combining behavioral tasks with pharmacology and genetically 
 modified mice we were able to show that mPFC 5-HT2aR are important for the
  retrieval of episodic like memories and their reconsolidation\, some of t
 he signaling cascade that appears to participate in this modulation and ho
 w mPFC 5-HT2aR might help the retrieval of weak memories.\n\nNoelia Weisst
 aub is a biologist from the Faculty of Exact and Natural Sciences of the U
 niversity of Buenos Aires\, 2 masters followed by PhD from Columbia Univer
 sity in New York (USA) with Dr Rene Hen and Dr Jay Gingrich\, where she ex
 plored the role of the 5-HT2a receptor in emotional control processes and 
 the action of hallucinogenic drugs. She followed with a postdoc in the Div
 ision of Translational Neurosciences of the Psychiatric Institute of New Y
 ork. She returned to Argentina within the roots program for repatriation o
 f human resources (PRH)\, first with a reintegration scholarship from CONI
 CET and then as a full independent researcher In 2009 laboratory within th
 e Systems Neuroscience Group at the School of Medicine of the University o
 f Buenos Aires. She co-directs the Molecular Cognition Laboratory. The res
 earch lines of the laboratory are intended to understand the cellular and 
 molecular and systems mechanisms of memory and forgetting and the role of 
 the serotonergic system in these processes.\n
LOCATION:Zoom meeting
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