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SUMMARY:Computational analysis of cancer genomes - Prof Nuria Lopez-Bigas 
 from Institute for Research in Biomedicine in Barcelona  
DTSTART:20201109T100000Z
DTEND:20201109T110000Z
UID:TALK153850@talks.cam.ac.uk
CONTACT:Anna Toporska
DESCRIPTION:Somatic mutations are the driving force of cancer genome evolu
 tion. Given the evolutionary principles of cancer\, one effective way to i
 dentify genes involved in cancer is by tracing the signals left by the pos
 itive selection of driver mutations across tumours. Prof Lopez-Bigas and h
 er team analyse thousands of tumour genomes to identify driver mutations i
 n the genome (results available in http://www.intogen.org). The analysis o
 f tumour cohorts provide valuable information to improve the interpretatio
 n of individual variants detected in newly sequenced tumours in clinical o
 r research settings. \nCancerGenomeInterpreter.org\, a tool designed to id
 entify driver mutations and biomarkers of drug response in individual tumo
 urs\, has been developed by Prof Lopez-Bigas and her lab.  Finally\, by an
 alysing more than 3500 whole-genomes of treated metastatic patients the mu
 tational footprints (or mutational signatures) of commonly used cancer tre
 atments were uncovered. These signatures allowed to measure the mutational
  toxicity of these treatments across patients and organs.\n
LOCATION:ZOOM (live)
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