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SUMMARY:Protein complexes subjected to tandem mass spectrometry reveal all
 osteric binding partners - Prof. Dame Carol Robinson\; University of Oxfor
 d
DTSTART:20210714T140000Z
DTEND:20210714T150000Z
UID:TALK154093@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Recent discoveries have enabled transmission into the gas phas
 e of membrane complexes from detergent micelles in solution. By maintainin
 g interactions between membrane and cytoplasmic subunits in the mass spect
 rometer\, it is now possible to investigate the effects of lipids\, nucleo
 tides and drugs on intact membrane assemblies. These investigations reveal
  allosteric and synergistic effects of small molecule binding and expose t
 he consequences of post-translational modifications. Whilst very insightfu
 l\, the choice of detergent can sometimes perturb interactions within the 
 membrane leading to changes in the lipid environment\, loss of small molec
 ules and disruption of protein interactions.  In my lecture\, I will prese
 nt recent progress in our quest to eject complexes directly from membrane 
 mimetics or native membranes and to fragment the small molecules harboured
  within them.\n\n\nJoin the webinar live using this link – https://zoom.
 us/j/91399302621
LOCATION:Online via zoom
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