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SUMMARY:Translation defects and neurological disease - Susan L Ackerman\, 
 PhD.  Professor\, Cellular and Molecular Biology  Steven W. Kuffler Chair 
 of Biology  University of California San Diego USA/HHMI
DTSTART:20201208T160000Z
DTEND:20201208T170000Z
UID:TALK154132@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Neurodegenerative disorders affect many people\, particularly 
 in the aging population. Yet the cause of these disorders is unknown for t
 he majority of the most prevalent forms of these diseases. Our laboratory 
 focuses on identifying the mechanisms underlying neuronal homeostasis in t
 he aging mammalian brain. Using a phenotype-driven approach\, we have iden
 tified several novel molecular mechanisms that underlie neuron death. Rece
 ntly\, we have extended this unbiased approach to identify genes that modi
 fy the expressivity of the phenotype caused by the primary mutation. Curre
 ntly\, our lab is focusing on the how changes in translation elongation\, 
 including those affecting ribosome processivity\, translational fidelity a
 nd tRNA expression\, impact neurodegeneration and neurophysiology\, and th
 e mechanisms underlying the cell type-specificity of mutations that disrup
 t translation elongation.\n\nZoom details:\n\nhttps://zoom.us/j/9528065566
 0?pwd=RzhzSlQvWXFVS1dVdURPUUxocElkQT09\nPasscode: 628922
LOCATION:Webinar - https://zoom.us/j/95280655660?pwd=RzhzSlQvWXFVS1dVdURPU
 UxocElkQT09 Passcode: 628922
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