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SUMMARY:The role of the KCC transporters in epithelial cancers: evidence f
 or involvement in cell migration\, proliferation and epithelial-mesenchyma
 l transition - Clive Ellory\, Department of Physiology\, Anatomy and Genet
 ics\, University of Oxford
DTSTART:20081203T163000Z
DTEND:20081203T173000Z
UID:TALK15416@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:The KCC family of transporters mediate Cl-dependent K loss fro
 m cells\, and were originally identified principally for their role in cel
 l volume regulation. The neuronal form KCC2 has also been shown to play an
  important role in neuronal development\, setting intracellular Cl levels 
 and GABA dependent inhibition. We have shown that KCC3 and KCC4 isoforms a
 re markedly upregulated in human cancer cells\, and affect not only ion tr
 ansport\, but invasion\, growth and EMT. Besides an effect linked to intra
 cellular Cl levels (presumably via  Cl-dependent kinases) direct effects o
 f the KCC proteins on trafficking and expression of adhesion molecules can
  be shown. These transporters may represent an important diagnostic correl
 ate for tumour malignancy and cancer growth.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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